So, each of those are used FOR the individual character, not for other characters, I'm pretty sure. The only possible exception would be Heal, I think. NPCs will use the first two but not the last two, as Irritation and Frustration are triggered by user input. IIRC, Irritation is when you are clicking on a character a lot, while Frustration is, as you say, asking them to do something they can't.